Thomas G Cotter Selected Research

Norgestrel (DL-Norgestrel)

1/2019	Norgestrel, a Progesterone Analogue, Promotes Significant Long-Term Neuroprotection of Cone Photoreceptors in a Mouse Model of Retinal Disease.
1/2018	Microglial-induced Müller cell gliosis is attenuated by progesterone in a mouse model of retinitis pigmentosa.
12/2016	The synthetic progestin norgestrel modulates Nrf2 signaling and acts as an antioxidant in a model of retinal degeneration.
4/2016	The synthetic progesterone Norgestrel is neuroprotective in stressed photoreceptor-like cells and retinal explants, mediating its effects via basic fibroblast growth factor, protein kinase A and glycogen synthase kinase 3β signalling.
1/2016	Progesterone receptor signalling in retinal photoreceptor neuroprotection.
1/2016	The synthetic progestin norgestrel acts to increase LIF levels in the rd10 mouse model of retinitis pigmentosa.
1/2016	Progesterone Attenuates Microglial-Driven Retinal Degeneration and Stimulates Protective Fractalkine-CX3CR1 Signaling.
5/2012	Norgestrel may be a potential therapy for retinal degenerations.
9/2011	Enhancing survival of photoreceptor cells in vivo using the synthetic progestin Norgestrel.

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Thomas G Cotter Research Topics

Disease

10	Neoplasms (Cancer) 01/2018 - 11/2003
10	Retinitis Pigmentosa (Pigmentary Retinopathy) 01/2018 - 07/2003
8	Retinal Degeneration 12/2016 - 07/2003
5	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2017 - 01/2012
4	Liver Diseases (Liver Disease) 03/2022 - 01/2020
4	Retinal Diseases 01/2019 - 04/2009
4	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 09/2011 - 07/2005
3	Non-alcoholic Fatty Liver Disease 10/2022 - 01/2020
3	Microscopic Colitis 11/2017 - 01/2017
3	Leukemia 01/2017 - 07/2005
3	Starvation 01/2016 - 12/2007
3	Genomic Instability 04/2015 - 01/2013
2	Fibrosis (Cirrhosis) 01/2022 - 07/2021
2	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 05/2021 - 06/2017
2	Autoimmune Diseases (Autoimmune Disease) 05/2021 - 11/2003
2	Inflammation (Inflammations) 11/2020 - 08/2003
2	Gliosis 01/2018 - 09/2012
2	Prostatic Neoplasms (Prostate Cancer) 12/2012 - 04/2004
2	Neoplasm Metastasis (Metastasis) 01/2012 - 03/2005
2	Neurodegenerative Diseases (Neurodegenerative Disease) 09/2009 - 12/2006
1	Pre-Eclampsia (Preeclampsia) 01/2022
1	Brain Death (Brain Dead) 01/2022
1	Esophageal and Gastric Varices (Esophageal Varices) 01/2022
1	Hemorrhage 01/2022
1	Hypertension (High Blood Pressure) 01/2022
1	Acute-On-Chronic Liver Failure 11/2021
1	Rheumatic Diseases (Rheumatism) 05/2021
1	Psoriasis (Pustulosis Palmaris et Plantaris) 05/2021
1	Alcoholic Hepatitis 01/2021
1	Congenital Heart Defects (Congenital Heart Defect) 01/2021
1	Chronic Hepatitis C 01/2019
1	Abdominal Pain (Pain, Abdominal) 01/2018
1	Weight Loss (Weight Reduction) 01/2018
1	Intermittent Claudication 11/2017
1	Hematoma 09/2017
1	Pneumonia (Pneumonitis) 06/2017
1	Diarrhea 03/2017
1	Celiac Disease (Celiac Sprue) 02/2017
1	Colorectal Neoplasms (Colorectal Cancer) 01/2017
1	Myeloid Leukemia (Leukemia, Myelocytic) 12/2016
1	Eye Diseases (Eye Disease) 01/2016
1	Colonic Neoplasms (Colon Cancer) 01/2012

Drug/Important Bio-Agent (IBA)

9	Norgestrel (DL-Norgestrel)FDA LinkGeneric 01/2019 - 09/2011
9	Retinaldehyde (Retinal)IBA 12/2016 - 07/2003
8	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2018 - 01/2012
5	AntioxidantsIBA 11/2020 - 10/2008
5	Progesterone FDA LinkGeneric 01/2019 - 01/2016
3	Budesonide (Pulmicort)FDA LinkGeneric 11/2017 - 01/2017
3	Pharmaceutical PreparationsIBA 02/2017 - 07/2005
3	Small Interfering RNA (siRNA)IBA 01/2017 - 01/2012
3	Progesterone CongenersIBA 12/2016 - 01/2016
3	Proteins (Proteins, Gene)FDA Link 09/2012 - 12/2007
3	CaspasesIBA 10/2007 - 07/2003
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 05/2021 - 11/2017
2	Biomarkers (Surrogate Marker)IBA 11/2020 - 01/2017
2	fms-Like Tyrosine Kinase 3IBA 01/2017 - 12/2016
2	Oncogene Proteins (Oncogene Protein)IBA 12/2016 - 05/2006
2	NADPH Oxidases (NAD(P)H oxidase)IBA 04/2015 - 08/2014
2	Phosphotransferases (Kinase)IBA 02/2013 - 04/2004
2	EnzymesIBA 12/2012 - 01/2012
2	Protein Isoforms (Isoforms)IBA 10/2007 - 02/2006
2	OsteopontinIBA 07/2005 - 03/2005
2	fas Receptor (CD95 Antigen)IBA 04/2004 - 11/2003
1	Cyclosporine (Ciclosporin)FDA LinkGeneric 01/2022
1	CytokinesIBA 05/2021
1	glecaprevir and pibrentasvirIBA 01/2019
1	Transcription Factors (Transcription Factor)IBA 01/2018
1	InterferonsIBA 01/2018
1	Prostaglandins AIBA 01/2018
1	Neuroprotective AgentsIBA 01/2018
1	Glial Fibrillary Acidic ProteinIBA 01/2018
1	Pentoxifylline (Trental)FDA LinkGeneric 11/2017
1	XanthineIBA 11/2017
1	nilotinib FDA Link 09/2017
1	Immunosuppressive Agents (Immunosuppressants)IBA 06/2017
1	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)IBA 03/2017
1	Norepinephrine (Noradrenaline)FDA LinkGeneric 03/2017
1	Serotonin (5 Hydroxytryptamine)IBA 03/2017
1	CyclodextrinsIBA 01/2017
1	Interleukin-3 Receptors (Interleukin 3 Receptor)IBA 01/2017
1	Surface Antigens (Surface Antigen)IBA 01/2017
1	1,2-distearoylphosphatidylethanolamine (DSPE)IBA 01/2017
1	DNA (Deoxyribonucleic Acid)IBA 01/2017
1	AntigensIBA 01/2017
1	EllipticinesIBA 02/2016
1	Progesterone Receptors (Progesterone Receptor)IBA 01/2016
1	Hormones (Hormone)IBA 01/2016
1	Leukemia Inhibitory FactorIBA 01/2016
1	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 04/2015
1	Vascular Endothelial Growth Factor Receptor-1 (fms-Like Tyrosine Kinase)IBA 04/2015
1	4- ethoxymethylene- 2- phenyl- 2- oxazoline- 5- one (phOx)IBA 04/2015
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 09/2012
1	Mitogen-Activated Protein Kinase 3IBA 09/2012
1	CollagenIBA 01/2012
1	Toll-Like Receptor 4IBA 01/2012

Therapy/Procedure

10	Liver Transplantation 10/2022 - 01/2020
7	Therapeutics 05/2021 - 10/2008
2	Drug Therapy (Chemotherapy) 09/2017 - 01/2017
1	Contraindications 01/2022
1	Transplantation 07/2021